Before joining "The Studio," O’Hara builds a long and acclaimed career in film and television, becoming known for iconic roles in comedies and character‑driven projects. She gains widespread recognition for her work in the sketch series "SCTV" and films such as "Home Alone" and "Beetlejuice," establishing her as a versatile performer with strong comedic and dramatic range.

O’Hara later appears in television series including "Schitt’s Creek," where her portrayal of Moira Rose earns major award recognition and showcases her ability to blend humor with heartfelt character work. These roles contribute to her reputation as a prominent figure in both ensemble casts and leading performances prior to starring in "The Studio."

In addition to her on‑screen performances, O’Hara brings depth to her roles through improvisation and creative collaboration, drawing on decades of experience working with different directors and ensembles across genres. Her wide body of work gives her a strong foundation for her role in the Hollywood satire.

Outside of acting on "The Studio," O’Hara’s legacy includes contributions to both film and television, and she remains celebrated for her influence on comedy and character acting across multiple generations of audiences and performers.